Afeni Shakur, the former Black Panther who overcame drug addiction and inspired the work of her rap icon son Tupac Shakur before guiding his estate after his murder, has died. She was 69.

Marin County sheriff’s deputies and firefighters responded to Shakur’s houseboat in Sausalito, Calif., Monday night after she fell ill and suffered a suspected heart attack, police said.

A family member and a close friend were present when she became unresponsive, cops said.

“At this point, there is nothing to indicate to us that there was any foul play, nothing suspicious about this other than this being sadly a natural event,” Marin County Sheriff’s Lt. Doug Pittman said.

Paramedics arrived around 9:30 p.m., and Shakur was rushed to Marin General Hospital, where she was treated for about an hour before she was pronounced dead, according to Pittman.

An autopsy was scheduled for Tuesday.

“It’s a sad day,” Tupac’s biological dad, Billy Garland, told the Daily News. “Her contributions to this world will always be remembered. We weren’t really active in each other’s lives, but the pain is magnified when it’s the mother of your child.”